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Darkojam Skies

larry — Mon, 15 Dec 2008 02:07:21 +0000

Echinocyte

larry — Wed, 10 Sep 2008 09:26:09 +0000

-Red cell with 30 or more, short blunt projections which are regularly distributed on their surface.

- Cells retain the central pallor.

•Usually artifactual— the result of slow drying under humid conditions.

-Sometimes are non-artifactual, indicating uremia or pyruvate kinase deficiency.

Dohle Body

larry — Wed, 10 Sep 2008 09:02:01 +0000

-Inclusion bodies that represent the remnants of free ribosomes of rough endoplasmic reticulum.

-Single or multiple, blue, grayish-blue, or greenish inclusions.

-Found in the cytoplasm of PMNs, bands or metamyelocytes.

-Often seen with toxic granulation and vacuoles.

Chediak-Higashi Granules

larry — Wed, 10 Sep 2008 09:01:28 +0000

-Giant, often round, red blue or greenish-gray granules of variable size are seen in the cytoplasm of leukocytes and sometimes normoblasts in patients with Cheidak-Stienbrick-Higashi syndrome.

-These granules represent abnormal lysosomes.

Blister Cell

larry — Wed, 10 Sep 2008 08:59:45 +0000

-Red cells containing one or two submembranous vacuoles.

-The vacuoles are the results of hemodynamic pressures that have forced red cells over obstacles such as thrombi or fibrin strands

Bite Cell

larry — Wed, 10 Sep 2008 08:59:13 +0000

-Red cells from which denatured, precipitated masses of hemoglobin have been pitted by the spleen. The precipitation is the result of oxidative injury to hemoglobin by drugs or by the denaturation of unstable mutant hemoglobins.

-The bites can range from large “bites” to tiny “nibbles”.

Basophillic Stippling

larry — Wed, 10 Sep 2008 08:58:30 +0000

-Fine, medium or coarse blue granules with uniform distribution within the red cell.

-Represents ribosomal RNA which is precipitated during staining.

-Found in conditions such as thalassemia, hemoglobinopathies, sideroblastic anemias, heavy metal poisioning and pyrimidine-5′- nucleotidase deficiency.

Basophil

larry — Wed, 10 Sep 2008 08:57:47 +0000

-The cells mimic the netrophils in size shape and nuclear maturation.

-Characterized by small to moderate number of coarse, densely stained granules of different sizes and shapes.

-The color of the granules is bluish-black but some may stain purple or purple-red.

-The granules are unevenly distributed and frequently overlie the nucleus.

Band

larry — Wed, 10 Sep 2008 08:57:03 +0000

-Same size or slightly smaller than metamyelocytes.

-Nucleus may be central or eccentric and is indented (to more than half of the distance to the farthest nuclear margin). The nucleus appears in the shape of a band, sausage, letter C or U. Small extensions of appendages of the nucleus may be seen so long as there is no filament connecting the appendages.

-The chromatin is coarse and clumpy.

-The N:C ratio is 1:1.5 to 1:2.

-It may not contain primary granules but does contain many secondary granules.

-Band forms do not contain nucleoli.

Alder-Reilly Granules

larry — Wed, 10 Sep 2008 08:56:12 +0000

-Resemble the large primary granules of promyelocytes.

-Large, purple of purplish-black, coarse azurophilic granules

-Characteristic of Alder-Reilly anomaly.